Maryam Saadat; Roya Malekloo; Marzieh Davoodi; Elham Sadat Afraz; Aysan Vaez; Asal Safarbalou; Ali Mohammad Falahati; Nasrollah Moradi-kor
Volume 4, Issue 5 , May 2022, , Pages 432-440
Abstract
This study evaluated the beneficial effects of quercetin nano-phytosome on inflammatory parameters in multiple sclerosis. The animals were divided into five groups, including Control, ...
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This study evaluated the beneficial effects of quercetin nano-phytosome on inflammatory parameters in multiple sclerosis. The animals were divided into five groups, including Control, 150 Quercetin, 300 Quercetin, 150 and 300 nano-phytosome of Quercetin. At the end of the study, serum levels of Granulocyte-macrophage colony stimulator (GMCSF), interleukin 1β (IL1β), interleukin 2 (IL2), interleukin 6 (IL6), interleukin 10 (IL10), interleukin 17 (IL17), Interleukin gamma (IFNγ) and tumor necrosis factor alpha (TNFα) were determined. The results showed that administration of Quercetin and its nano-phytsome significantly decreased the levels of IL-1β, IL-2, IL-6, IL-17, IFN-γ, TNF-α and GM-CSF and increased IL-10 in comparison to the control group. The treated animals with nano-phytsome significantly decreased IL-2, IL-1β, IL-17, IL-6, IFN-γ, TNF-α and GM-CSF and increased IL-10 compared with Quercetin group. Quercetin nanophytosomes can be used to effectively improve inflammation. We recommend using quercetin nanophytosomes to reduce inflammation in patients with multiple sclerosis.
